Proyectos:

• 2018-2020: Proyecto FONDECYT N° 1180867. Beyond proteins, genes and mutations: the hidden non-coding nature of the drug resistance in sea lice. Dr. Cristian Gallardo (PI). (M$198.000 CLP).
• 2017-2019: Proyecto FONDECYT N° 3170152. Epidemiología de la co-infección de Caligus rogercresseyi y Piscirickettsia salmonis en salmónidos de cultivo en Chile. Dr. Gabriel Arriagada (PI), Dr. Cristian Gallardo (Co-PI). (M$65.000 CLP).
• 2017-2020: FONDECYT Nº1161512. Inner-shelf regimes of hypoxia in an upwelling region: spatial heterogeneity and implications for coastal benthic ecology. Dr. Fabián Tapia (PI), Dr. Cristian Gallardo (Co-PI). (M$198.000 CLP).
• 2017-2018: Contratos tecnológicos para la innovación (COTE). Desarrollo de nuevos prototipos de vacunas vivas atenuadas contra SRS basados en análisis genéticos de P. Salmonis (17COTE-72396). CORFO, Ministerio de Economía, Chile. Dr. Cristian Gallardo (PI). (M$150.000 CLP).
• 2017-2019: “CaligusLIFE: Investigación científica de excelencia para la comprensión de la biología de Caligus rogercresseyi y su aplicación en estrategias de control de la caligidosis en la industria del salmón”. Programa para la Gestión Sanitaria en Acuicultura, FIE 2015-V014-SERNAPESCA, Chile. Dr. Cristian Gallardo (PI). (M$798.000 CLP).
• 2017-2019: Proyecto FONDEF IDeA dos Etapas. Utilización de extracto de Olivo rico en hidroxitirosol como aditivo en la alimentación de Seriola lalandi. Dr. Cristian Gallardo (Co-PI). (M$180.000 CLP).
• 2017-2019: Laboratorio de referencia de caligus: caracterización de cepas obtenidas desde la región de Magallanes y comparación con ejemplares de referencia, Programa para la Gestión Sanitaria en Acuicultura, FIE 2015-V014, SERNAPESCA, Chile. Dr. Cristian Gallardo (PI). (M$200.000 CLP).
• 2012-2025: Proyecto FONDAP Nº1510027. Interdisciplinary Center for Aquaculture Research (INCAR), Fourth National Competition for research Centers of Excellence in priority Areas,. Dr. C. Gallardo-Escárate, Deputy director. (M$4.250.000 CLP).

Publicaciones:

• 141. Arriagada, G., Valenzuela-Muñoz, V., Arriagada, A., Brossard, M., Montecino, K., Lara, M., Gallardo, A., Gallardo-Escárate, C. (2019). First report of the sea louse Caligus rogercresseyi found in farmed Atlantic salmon in the Magallanes region, Chile. (2018). Aquaculture, 512: 734386. Doi: 10.1016/j.aquaculture.2019.734386.
• 142. Núñez-Acuña, G., Gallardo-Escárate, C., Skiftesvik, A. B., Fields, D. M., & Browman, H. I. (2019). Silencing of ionotropic receptor 25a decreases chemosensory activity in the salmon louse Lepeophtheirus salmonis during the infective stage. Gene, 697: 35-39. Doi: 10.1016/j.gene.2019.02.012.
• 143. Gallardo-Escárate, C., Valenzuela-Muñoz, V., Núñez-Acuña, G., Carrera, C., Gonçalves, A. T., Valenzuela-Miranda, D. & Roberts, S. 2019. Catching the complexity of salmon-louse interactions. Fish & shellfish immunology. 90: 199-209. Doi.org/10.1016/j.fsi.2019.04.065.
• 144. Gallardo‐Escárate, C., Arriagada, G., Carrera, C., Gonçalves, A. T., Nuñez‐Acuña, G., Valenzuela‐Miranda, D., & Valenzuela‐Muñoz, V. 2019. The race between host and sea lice in the Chilean salmon farming: a genomic approach. Reviews in Aquaculture. 11(2), 325-339. Doi: 10.1111/raq.12334.
• 145. Rey-Campos, M., Moreira, R., Valenzuela-Muñoz, V., Gallardo-Escárate, C., B. Novoa & A. Figueras. (2019). High individual variability in the transcriptomic response of Mediterranean mussels to Vibrio reveals the involvement of myticins in tissue injury. Scientific Reports. 9:3569. Doi: 10.1038/s41598-019-39870-3.
• 146. Rivas-Aravena, A., Fuentes-Valenzuela, M., Escobar-Aguirre, S., Gallardo-Escárate, C., Molina, A., J. Antonio Valdés. (2019). Transcriptomic response of rainbow trout (Oncorhynchus mykiss) skeletal muscle to Flavobacterium psychorophilum. Comparative Biochemistry and Physiology – Part D. 31: 100596. Doi: 10.1016/j.cbd.2019.100596.
• 147. Arriagada, G., Hamilton-West, C., Nekouei, O., Foerster, C., Muller, A., Lara, M., C. Gallardo-Escárate. (2019). Caligus rogercresseyi infestation is associated with Piscirickettsia salmonis-attributed mortalities in farmed slmonids in Chile. Preventive Veterinary Medicine. 171: 104771. Doi: 10.1016/j.prevetmed.2019.104771.
• 148. Valenzuela-Muñoz, V., Pereiro, P., Álvarez-Rodríguez, M., Gallardo-Escárate, C., Figueras, A., & Novoa, B. 2019. Comparative modulation of lncRNAs in wild-type and RAG1 heterozygous mutant zebrafish exposed to an immune challenge with Spring Viremia of Carp Virus (SVCV). Scientific Reports. 9:3569. Doi: 10.1038/s41598-019-39870-3.
• 149. Arriagada, G., Figueroa, J., Marín, S., Arriagada, A. M., Lara, M., Gallardo‐Escárate, C. (2019). First report of the reduction in treatment efficacy of the organophosphate azamethiphos against the sea lice Caligus rogercresseyi (Boxshall & Bravo, 2000). Aquaculture Research, Doi: 10.1111/are.14334.
• 150. Valenzuela-Muñoz, V., Valenzuela-Miranda, D., Gonçalves, A.T., Novoa, B., Figueras, A., Gallardo-Escárate, C. 2020. Induced‑iron overdose modulate the immune response in Atlantic salmon increasing the susceptibility to Piscirickettsia salmonis infection. Aquaculture. 521: 735058. Doi.org/10.1016/j.aquaculture.2020.735058.
• 151. Valenzuela-Muñoz, V., Gallardo-Escárate, A., Sáez-Vera, C., Garcés, F., Bonfatti, F., and C. Gallardo-Escárate. 2019. More than bubbles: in vivo assessment and transcriptome modulation of Caligus rogercresseyi and Atlantic salmon exposed to hydrogen peroxide (PARAMOVE®). Aquaculture, 522: 35170. Doi: 10.1016/j.aquaculture.2020.735170.
• 152. Gonçalves, A. T., Collipal-Matamal, R., Valenzuela-Muñoz, V., Nuñez-Acuña1, G., Valenzuela-Miranda, D., C. Gallardo-Escárate. 2019. Nanopore sequencing of microbial communities reveals a potential role of sea lice as reservoir for fish pathogens. Scientific Reports. 10: 2895. Doi.org/10.1038/s41598-020-59747-0.
• 153. Gonçalves, A. T., V. Valenzuela-Muñoz, C. Gallardo-Escárate. 2020. Brain microRNAs in rainbow trout are modulated through functional additives and fish density. Aquaculture. 519: 734754. Doi: 10.1016/j.aquaculture.2019.734754.
• 154. Valenzuela-Miranda, D., Valenzuela-Muñoz, V., Núñez-Acuña, G. and C. Gallardo-Escárate. 2020. Long-term serial culture of Piscirickettsia salmonis leads to a genomic and transcriptomic reorganization affecting bacterial in vitro virulence. Aquaculture. 529: 735634. Doi: 10.1016/j.aquaculture.2020.735634.
• 155. Sáez-Vera, C., G. Núñez-Acuña & C. Gallardo-Escárate. 2019. Time-to-response bioassay coupled to DNA markers (ET50-PCR): A novel method to test delousing drug sensitivity in the sea louse Caligus rogercresseyi. Aquaculture. submitted.
• 156. Núñez-Acuña, P., Gallardo-Escárate, A., Sáez-Vera, C., Valenzuela-Muñoz, V., Núñez-Acuña, G. and Gallardo-Escárate, C. 2019. Effect of temperature and salinity on the life cycle and morphological development of Caligus rogercresseyi (Copepoda: Caligidae). Aquaculture. Submitted.
• 157. Valenzuela-Muñoz, V., Valenzuela-Miranda D., Gallardo-Escárate, C. 2019. How temperature and salinity could drive salmonid immune responses against the sea lice? inferring molecular players by depth transcriptome analyses. Fish & shellfish immunology. Submitted.
• 158. Núñez-Acuña, G., Sáez-Vera, C., Valenzuela-Muñoz, C., Arriagada, G. & C. Gallardo-Escárate. 2019. Tackling the molecular drug sensitivity in the sea louse Caligus rogercresseyi based on coding/non-coding RNA interactions. Parasite & Vectors, Submitted.
• 159. Carrera-Naipil, C., Casuso, A., Morales, M. F., Valenzuela-Muñoz, V., Nuñez-Acuña, G., and C. Gallardo-Escárate. 2019. Molecular and functional characterization of Caligus rogercresseyi Vitellogenin: post-transcriptional modulation and putative immune role. Gene. Submitted.
• 160. Sáez-Vera, C., G. Núñez-Acuña & C. Gallardo-Escárate. 2021. Sensitivity assessment to azamethiphos by time-to-response bioassay and biomarkersin the sea louse Caligus rogercresseyi. Aquaculture. 546 (2022)737340. DOI: 10.1016/j.aquaculture.2021.737340.
  

Congresos internacionales:

• 191. Gallardo-Escárate, C. Catching the complexity of salmon-louse interactions: a functional genomics approach. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th, 2019.
• 192. Núñez-Acuña, G., V. Valenzuela-Muñoz, C. Sáez-Vera & C. Gallardo-Escárate. Temperature drives the immune respose in atlantic salmon infected with sea lice: novel insights through transcriptome sequencing analyses. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th, 2019.
• 193. Valenzuela-Muñoz, V., D. Valenzuela-Miranda & C. Gallardo-Escárate. Iron overload alters the immune response in atlantic salmon and increases the susceptibility to Piscirickettsia salmonis infection. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th, 2019.
• 194. Leal, Y., V. Valenzuela-Muñoz, B. Benavente, C. Carrera-Naipil, A. Casuso & C. Gallardo-Escárate. Role of sea lice secretome in host-parasite interaction: immune modulation of SHK-1cells exposed to Caligus rogercresseyi secretome. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th, 2019.
• 195. Valenzuela-Miranda, D., & C. Gallardo-Escárate. Genomics for the understanding of the host-pathogen interaction: the case of the atlantic salmon and Piscirickettsia salmonis. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th, 2019.
• 196. Núñez-Acuña, G., C. Saez-Vera, S. Sanhueza-Guevara, C. Fernandez & C. Gallardo-Escárate. Pesticide drugs used against sea lice cause transcriptome changes in the early stages of the non-target species Choromytilus chorus. 3rd International Conference on Fish & Shellfish immunology (ISFSI), Las Palmas de Gran Canarias, España. June 16th-20th,
• 197. Gallardo-Escárate, C., The dark matter of the mussel’s genome: long non-coding RNAs as key players in Mytilus. Third International Symposium Advances in Marine Mussel Research, Chioggia, 26-28 August 2019.
• 198. Valenzuela-Muñoz, V., Benavente, B., Gallardo-Escárate, C., Bantam miRNA expressed in the sea louse modulates the fish immune response. II Molecular Biosystems Conference, Eukaryotic Gene Regulation & Functional Genomics. Puerto Varas, Chile. Sept 30 – Oct 4, 2019.

Patentes:

1.- Solicitud de Patente en trámite (2010): Procedimiento para criopreservación de espermatozoides en moluscos. Chile.
2.- Solicitud Patente de Patente en trámite (2010): Kit para trazabilidad de semillas de abalón. Chile.
3.- Solicitud patente de Patente en trámite (2010): Procedimiento de hibridación entre abalón rojo y verde. Chile.
4.- Marca Comercial de semillas híbridas de abalón. Chile.
5.- Péptidos recombinantes con actividad inmunomoduladora en salmones de cultivo contra el copépodo ectoparásito Caligus rogercresseyi. (2015)